Cancer de prostate wikipedia

Cancer de prostată. Cancerul de prostată este o formă de cancer care se dezvoltă în prostată, o glandă aflată la intersecția aparatului urinar cu cel genital la bărbați. Mare majoritate a cancerelor de prostată se dezvoltă lent, cu toate acestea, există cazuri în, Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.A copy of the license is included in the section entitled GNU Free Documentation License.

Cancer de prostate wikipedia

Cancer de prostate wikipedia
Which option is best depends on Cancer de prostate wikipedia stage, the Gleason score, and the PSA level. The Gleason grading system is used to help evaluate the prognosis and helps guide therapy. Prostate cancer that is only present in the prostate is often treated with either surgical removal of the prostate or with radiotherapy or by the insertion of small radioactive particles of iodine or palladiumcalled brachytherapy. Oncology Letters. The oncoprotein BCL-2 is associated with the development of androgen-independent prostate cancer, due to its high levels of expression in androgen-independent tumours in advanced stages. National Cancer Institute. Integrative Cancer Therapies. Blocking the formation of 5-HETE, by inhibiting 5-lipoxygenase, results in massive apoptosis of human prostate cancer cells Urology Match.

Nature Communications. Cancer de prostate wikipedia has been suggested the most promising approach may be to co-target this family with other pathways including PI3K.

Cancer de la prostate — Wikipédia

Câncer de próstata – Wikipédia, a enciclopédia livre
Os exames dos ossos mostram aparência osteoblástica devido a uma densidade óssea aumentada nas áreas em que há metástase óssea – em oposição ao que é observado em muitos outros cânceres que metastatizam. Se requiere anestesia epidural o general durante este procedimiento. The internal structure of the prostate has been described using both lobes and zones. Journal of Visualized Experiments Therefore, focal therapy targeted towards the index lesion might effectively treat prostate cancer while preserving the remainder of the gland. Cancer de prostate wikipedia the vas deferens deposits seminal fluid into Cancer de prostate wikipedia prostatic urethra, and secretions from the prostate are included in semen content, prostate cancer may also cause problems with sexual function and performance, such as difficulty achieving erection or painful ejaculation.

Preventive Services Task Force». More recently, a combination of Cancer de prostate wikipedia point and psychological therapy has proved effective for category III prostatitis as well. According to information from the Men After Prostate Surgery MAPS randomized control trial, pelvic floor muscle training was not shown to be therapeutic or cost effective in improving urinary continence.

Consuming fruits and vegetables has been found to be of little preventive benefit. The consumption of milk may be related to prostate cancer. Lower blood levels of vitamin D may increase risks. Some links have been established between prostate cancer and medications, medical procedures, and medical conditions. Prostatitis infection or inflammation may increase risk.

In particular, infection with the sexually transmitted infections Chlamydia , gonorrhea , or syphilis seems to increase risk. Papilloma virus has been proposed to have a potential role, but as of , the evidence was inconclusive; [56] as of , the increased risk was debated. Although some evidence from prospective cohort studies indicates that frequent ejaculation may reduce prostate cancer risk, [58] no randomized controlled trials reported this benefit.
The prostate is part of the male reproductive system that helps make and store seminal fluid. In adult men, a typical prostate is about 3 cm long and weighs about 20 g. The prostate surrounds part of the urethra , the tube that carries urine from the bladder during urination and semen during ejaculation. Superiorly, the prostate base is contiguous with the bladder outlet. Inferiorly, the prostate’s apex heads in the direction of the urogenital diaphragm, which is pointed anterio-inferiorly.

The prostate can be divided into four anatomic spaces: peripheral, central, transitional, and anterior fibromuscular stroma. The central space contains the superior portion of the prostate including the most proximal aspects of the urethra and bladder neck.
The transitional space is located just anterior to the central space and includes urethra distal to the central gland urethra. The neurovascular bundles course along the posterolateral prostate surface and penetrate the prostatic capsule there as well. None is found in the anterior fibromuscular stroma since no glands are in that anatomic space. The prostate glands require male hormones , known as androgens , to work properly. Androgens include testosterone , which is made in the testes ; dehydroepiandrosterone , made in the adrenal glands ; and dihydrotestosterone , which is converted from testosterone within the prostate itself. Androgens are also responsible for secondary sex characteristics such as facial hair and increased muscle mass.
Because of the prostate’s location, prostate diseases often affect urination, ejaculation, and rarely defecation.

In prostate cancer, the cells of these glands mutate into cancer cells. Most prostate cancers are classified as adenocarcinomas , or glandular cancers, that begin when semen-secreting gland cells mutate into cancer cells. The region of the prostate gland where the adenocarcinoma is most common is the peripheral zone. Initially, small clumps of cancer cells remain within otherwise normal prostate glands, a condition known as carcinoma in situ or prostatic intraepithelial neoplasia PIN.
Although no proof establishes that PIN is a cancer precursor, it is closely associated with cancer. Over time, these cells multiply and spread to the surrounding prostate tissue the stroma forming a tumor. Eventually, the tumor may grow large enough to invade nearby organs such as the seminal vesicles or the rectum, or tumor cells may develop the ability to travel in the bloodstream and lymphatic system. Prostate cancer is considered a malignant tumor because it can invade other areas of the body.

This invasion is called metastasis. Prostate cancer most commonly metastasizes to the bones and lymph nodes , and may invade the rectum, bladder , and lower ureters after local progression. The route of metastasis to bone is thought to be venous , as the prostatic venous plexus draining the prostate connects with the vertebral veins. The prostate is a zinc -accumulating, citrate -producing organ. Transport protein ZIP1 is responsible for the transport of zinc into prostate cells. One of zinc’s important roles is to change the cell’s metabolism to produce citrate, an important semen component. The process of zinc accumulation, alteration of metabolism, and citrate production is energy inefficient, and prostate cells require enormous amounts of energy ATP to accomplish this task.
Prostate cancer cells are generally devoid of zinc. Prostate cancer cells save energy by not making citrate, and use the conserved energy to grow, reproduce and spread. The absence of zinc is thought to occur via silencing the gene that produces ZIP1. It is called a tumor suppressor gene product for the gene SLC39A1.

The cause of the epigenetic silencing is unknown. Strategies that transport zinc into transformed prostate cells effectively eliminate these cells in animals. Zinc inhibits NF-κB pathways, is antiproliferative, and induces apoptosis in abnormal cells. Unfortunately, oral ingestion of zinc is ineffective since high concentrations of zinc into prostate cells is not possible without ZIP1. Loss of cancer suppressor genes, early in prostatic carcinogenesis, have been localized to chromosomes 8p , 10q , 13q , and 16q.
P53 mutations in the primary prostate cancer are relatively low and are more frequently seen in metastatic settings, hence, p53 mutations are a late event in the pathology. Loss of the retinoblastoma RB protein induces androgen receptor deregulation in castration-resistant prostate cancer by deregulating ‘ E2F1 expression.

RUNX2 is a transcription factor that prevents cancer cells from undergoing apoptosis, thereby contributing to cancer development. The androgen receptor helps cancer cells to survive. Research has not yet proven that the potential benefits of testing outweigh the harms of testing and treatment. Starting at age 50, 45 if African American or brother or father suffered from condition before age 65 talk to your doctor about the pros and cons of testing so you can decide if testing is the right choice for you.
Several other tests can be used to gather information about the prostate and the urinary tract. Digital rectal examination may allow a doctor to detect prostate abnormalities. Cystoscopy shows the urinary tract from inside the bladder, using a thin, flexible camera tube inserted in the urethra.

Transrectal ultrasonography creates a picture of the prostate using sound waves from a probe in the rectum, but the only test that can fully confirm the diagnosis of prostate cancer is a biopsy , the removal of small pieces of the prostate for microscopic examination. Ultrasound and magnetic resonance imaging MRI are the two main imaging methods used for prostate cancer detection.
On MRI, the central and transitional zones both have lower T2 signal than the peripheral zone. Since the central and transitional zones cannot be distinguished from each other, they can be best described as the central gland on MRI. Thus, the peripheral gland has a higher signal on T2WI than the central gland. In the peripheral gland, prostate cancer appears as a low-intensity lesion. However, in the central gland, low-intensity lesions cannot be distinguished from the low-intensity central gland. Diffusion restriction is instrumental in identifying and characterizing central gland lesions. Combined diffusion-weighted DW imaging and dynamic contrast-enhanced MRI for distinguish malignant from benign prostate lesions can be used.

The merged images, of DW and MRI with dynamic contrast enhancement, can visualise areas with low signal intensity and fast wash-out effect – characteristic of carcinomas. Other regions can be described on MRI. The anterior fibromuscular stroma and the prostate capsule along the posterior and lateral prostate have a low T2WI signal, in contrast with the bright signal of the peripheral zone.
Extraprostatic extension can be seen with disruption of capsule integrity. Following an MRI, regions of interest within the scan which may be cancer are often graded on a likelihood scale between 1 and 5. Prostate MRI is also used for surgical planning for robotic prostatectomy. It helps surgeons decide whether to resect or spare the neurovascular bundle, determine return to urinary continence, and help assess surgical difficulty. The biological properties which determine whether or not a tumour is visible on MRI is poorly understood.

One theory is that tumour cells undergo several genetic changes during transformation which alter the cellular rate of growth and formation of new blood vessels, leading to tumours with more aggressive histological patterns, hypoxic regions and increased cell density among other features.
Some studies have linked the presence of rare histological patterns within the tumour such as cribriform pattern. Ultrasound imaging can be obtained transrectally and is used during prostate biopsies. On Color Doppler, the lesions appear hypervascular. If cancer is suspected, a biopsy is offered expediently. During a biopsy, a urologist or radiologist obtains tissue samples from the prostate via either the rectum or the perineum. Prostate biopsies are routinely done on an outpatient basis and rarely require hospitalization. Antibiotics should be used to prevent complications such as fever , urinary tract infections , and sepsis [90] even if the most appropriate course or dose is undefined. A histopathologic diagnosis mainly includes assessment of whether a cancer exists, as well as any subdiagnosis, if possible.

Histopathologic subdiagnosis has implications for the possibility and methodology of Gleason scoring. Alkaline phosphatase is more elevated in metastatic than non-metastatic cells. The Gleason grading system is used to help evaluate the prognosis and helps guide therapy. A Gleason score is based upon the tumor’s appearance. Pathological scores range from 2 through 10, with a higher number indicating greater risks and higher mortality. Tissue samples can be stained for the presence of PSA and other tumor markers to determine the origin of malignant cells that have metastasized.
The oncoprotein BCL-2 is associated with the development of androgen-independent prostate cancer, due to its high levels of expression in androgen-independent tumours in advanced stages. The upregulation of BCL-2 after androgen ablation in prostate carcinoma cell lines and in a castrated-male rat model further established a connection between BCL-2 expression and prostate cancer progression. An important part of evaluating prostate cancer is determining the stage , or degree of spread.

Knowing the stage helps define prognosis and is useful when selecting therapies.
Its components include the size of the tumor, the number of involved lymph nodes , and the presence of any other metastases. The most important distinction made by any staging system is whether the cancer is confined to the prostate. Several tests can be used to look for evidence of spread. Medical specialty professional organizations recommend against the use of PET scans , CT scans , or bone scans when a physician stages early prostate cancer with low risk for metastasis.
Bone scans should reveal osteoblastic appearance due to increased bone density in the areas of bone metastasis —the reverse of what is found in many other metastatic cancers. After a biopsy, a pathologist examines the samples under a microscope.

If cancer is present, the pathologist reports the grade of the tumor. The grade tells how much the tumor tissue differs from normal prostate tissue and suggests how fast the tumor is likely to grow. The pathologist assigns a Gleason number from 1 to 5 for the most common pattern observed under the microscope, then does the same for the second-most common pattern.
The sum of these two numbers is the Gleason score. The Whitmore-Jewett stage is another method. The data on the relationship between diet and prostate cancer are poor. Fish may lower prostate-cancer deaths, but does not appear to affect occurrence. Regular exercise may slightly lower risk, especially vigorous activity.

In those who are regularly screened, 5-alpha-reductase inhibitors finasteride and dutasteride reduce the overall risk of prostate cancer.
Data are insufficient to determine if they affect fatality risk and they may increase the chance of more serious cases. Prostate cancer screening searches for cancers in those without symptoms. Options include the digital rectal exam and the PSA blood test. American Urological Association AUA guidelines call for weighing the uncertain benefits of screening against the known harms associated with diagnostic tests and treatment. The AUA recommends that shared decision-making should control screening for those 55 to 69, and that screening should occur no more often than every two years.
The first decision is whether treatment is needed. Low-grade forms found in elderly men often grows so slowly that treatment is not required. Approaches in which treatment is postponed are termed „expectant management”.

Which option is best depends on disease stage, the Gleason score, and the PSA level. Other important factors are age, general health and a person’s views about potential treatments and their possible side effects.
Because most treatments can have significant side effects , such as erectile dysfunction and urinary incontinence , treatment discussions often focus on balancing the goals of therapy with the risks of lifestyle alterations. A review found that more research focused on person-centered outcomes is needed to guide patients. Guidelines for specific clinical situations require estimation of life expectancy. Therefore, interest grew in aggressive treatment modalities such as surgery or radiation even for localized disease. Alternatively, an item questionnaire was proposed to learn whether patients have adequate knowledge and understanding of their treatment options.

In one study, most of those who were newly diagnosed correctly answered fewer than half of the questions. Many men diagnosed with low-risk prostate cancer are eligible for active surveillance. The tumor is carefully observed over time, with the intention of initiating treatment if signs of progression appear. Active surveillance is not synonymous with watchful waiting , a term which implies no treatment or specific program of monitoring, with the assumption that only palliative treatment would be used if advanced, symptomatic disease develops. Active surveillance involves monitoring the tumor for growth or symptoms, which trigger treatment.
This approach is not used for aggressive cancers, and may cause anxiety for people who wrongly believe that all cancers are deadly or that their condition is life-threatening. Both surgical and nonsurgical treatments are available, but treatment can be difficult, and combinations can be used.

Hormonal therapy and chemotherapy are often reserved for metastatic disease. Exceptions include local or metastasis-directed therapy with radiation may be used for advanced tumors with limited metastasis.
Cryotherapy the process of freezing the tumor , hormonal therapy, and chemotherapy may be offered if initial treatment fails and the cancer progresses. Sipuleucel-T , a cancer vaccine , was reported to offer a four-month increase in survival in metastatic prostate cancer. If radiation therapy fails, radical prostatectomy may be an option, [] though it is a technically challenging surgery. Non-surgical treatment may involve radiation therapy, chemotherapy, hormonal therapy, external beam radiation therapy, and particle therapy , high-intensity focused ultrasound, or some combination. Prostate cancer that persists when testosterone levels are lowered by hormonal therapy is called castrate-resistant prostate cancer CRPC.

Previously considered „hormone-refractory prostate cancer” or „androgen-independent prostate cancer”, the term CRPC emerged because these cancers show reliance upon hormones, particularly testosterone, for androgen receptor activation. The cancer chemotherapeutic docetaxel has been used as treatment for CRPC with a median survival benefit of 2 to 3 months. The second line hormonal therapy abiraterone increases survival by 4. Both abiraterone and enzalutamide are currently in clinical trials in those with CRPC who have not previously received chemotherapy. Not all patients respond to androgen signaling-blocking drugs.
Certain cells with characteristics resembling stem cells remain unaffected. For patients with metastatic prostate cancer that has spread to their bones, doctors use a variety of bone-modifying agents to prevent skeletal complications and support the formation of new bone mass. Radical prostatectomy is considered the mainstay of surgical treatment of prostate cancer, where the surgeon removes the prostate, seminal vesicles , and surrounding lymph nodes.

It can be done by an open technique a skin incision at the lower abdomen , or laparoscopically. Radical retropubic prostatectomy is the most commonly used open surgical technique. Transurethral resection of the prostate is the standard surgical treatment for benign enlargement of the prostate. The procedure is done under spinal anesthesia, a resectoscope is inserted inside the penis and the extra prostatic tissue is cut to clear the way for the urine to pass. The two main complications encountered after prostatectomy and prostate radiotherapy are erectile dysfunction and urinary incontinence , mainly stress-type. Most men regain continence within 6 to 12 months after the operation, so doctors usually wait at least one year before resorting to invasive treatments.
Stress urinary incontinence usually happens after prostate surgery or radiation therapy due to factors that include damage to the urethral sphincter or surrounding tissue and nerves. The prostate surrounds the urethra, a muscular tube that closes the urinary bladder.

Any of the mentioned reasons can lead to incompetent closure of the urethra and hence incontinence. More invasive surgical treatment can include the insertion of a urethral sling or an artificial urinary sphincter , which is a mechanical device that mimics the function of the urethral sphincter, and is activated manually by the patient through a switch implanted in the scrotum. The latter is considered the gold standard in patients with moderate or severe stress urinary incontinence.
Erectile dysfunction happens in different degrees in nearly all men who undergo prostate cancer treatment, including radiotherapy or surgery; however, within one year, most of them will notice improvement. If nerves were damaged, this progress may not take place. Pharmacological treatment includes PDE-5 inhibitors such as viagra or cialis , or injectable intracavernous drugs injected directly into the penis prostaglandin E1 and vasoactive drug mixtures. Other nonpharmacological therapy includes vacuum constriction devices and penile implants.

Many prostate cancers are not destined to be lethal, and most men will ultimately not die as a result of the disease. Mortality varies widely across geography and other elements. In patients who undergo treatment, the most important clinical prognostic indicators of disease outcome are the stage, pretherapy PSA level, and Gleason score.
The higher the grade and the stage, the poorer the prognosis. Nomograms can be used to calculate the estimated risk of the individual patient. The predictions are based on the experience of large groups of patients. After remission, an androgen-independent phenotype typically emerges, wherein the median overall survival is 23—37 months from the time of initiation of androgen ablation therapy. Several tools are available to help predict outcomes, such as pathologic stage and recurrence after surgery or radiation therapy.
Life expectancy projections are averages for an entire male population, and many medical and lifestyle factors modify these numbers.

For example, studies have shown that a year-old man will lose 3. If he is both overweight and a smoker, he will lose 6. No evidence shows that either surgery or beam radiation has an advantage over the other in this regard. The lower death rates reported with surgery appear to occur because surgery is more likely to be offered to younger men with less severe cancers. Insufficient information is available to determine whether seed radiation extends life more readily than the other treatments, but data so far do not suggest that it does.
Men with low-grade disease Gleason 2—4 were unlikely to die of prostate cancer within 15 years of diagnosis. Men with high-grade disease Gleason 8—10 experienced high mortality within 15 years of diagnosis, regardless of their age. Rates vary widely between countries. The average annual incidence rate of prostate cancer between and among Chinese men in the United States was 15 times higher than that of their counterparts living in Shanghai and Tianjin, [] [] [] but these high rates may be affected by higher rates of detection.

Prostate cancer is the third-leading cause of cancer death in men, exceeded by lung cancer and colorectal cancer. Cases ranged from an estimated , in [] to an estimated , In Deaths held steady around 30, in [] and 29, in Age-adjusted incidence rates increased steadily from through , with particularly dramatic increases associated with the spread of PSA screening in the late s, later followed by a fall in incidence. Declines in mortality rates in certain jurisdictions may reflect the interaction of PSA screening and improved treatment.
The estimated lifetime risk is about Prostate cancer is more common in the African American population than the White American population. Prostate cancer is the third-leading type of cancer in Canadian men. In , around 4, died and 21, men were diagnosed with prostate cancer. In Europe in , it was the third-most diagnosed cancer after breast and colorectal cancers at , cases.

In the United Kingdom, it is the second-most common cause of cancer death after lung cancer, where around 35, cases are diagnosed every year, of which around 10, are fatal. The prostate was first described by Venetian anatomist Niccolò Massa in , and illustrated by Flemish anatomist Andreas Vesalius in The first treatments were surgeries to relieve urinary obstruction.
Removal of the gland was first described in , [] and radical perineal prostatectomy was first performed in by Hugh H. Young at Johns Hopkins Hospital. Surgical removal of the testes orchiectomy to treat prostate cancer was first performed in the s, with limited success. Transurethral resection of the prostate TURP replaced radical prostatectomy for symptomatic relief of obstruction in the middle of the 20th century because it could better preserve penile erectile function. Radical retropubic prostatectomy was developed in by Patrick Walsh. In , Charles B. Huggins published studies in which he used estrogen to oppose testosterone production in men with metastatic prostate cancer.

GnRH receptor agonists, such as leuprorelin and goserelin , were subsequently developed and used to treat prostate cancer. Radiation therapy for prostate cancer was first developed in the early 20th century and initially consisted of intraprostatic radium implants. External beam radiotherapy became more popular as stronger [X-ray] radiation sources became available in the middle of the 20th century. Brachytherapy with implanted seeds for prostate cancer was first described in Systemic chemotherapy for prostate cancer was first studied in the s. The initial regimen of cyclophosphamide and 5-fluorouracil was quickly joined by regimens using other systemic chemotherapy drugs. People with prostate cancer generally encounter significant disparities in awareness, funding, media coverage, and research—and therefore, inferior treatment and poorer outcomes—compared to other cancers of equal prevalence.
Waiting time between referral and diagnosis was two weeks for breast cancer but three months for prostate cancer.

A report by the U. The Times also noted an „anti-male bias in cancer funding” with a four-to-one discrepancy in the United Kingdom by both the government and by cancer charities such as Cancer Research UK. Disparities extend into detection, with governments failing to fund or mandate prostate cancer screening while fully supporting breast cancer programs. For example, a report found 49 U. Prostate cancer experiences significantly less media coverage than other, equally prevalent cancers, outcovered 2.
Prostate Cancer Awareness Month takes place in September in a number of countries. A light blue ribbon is used to promote the cause. Enzalutamide is a nonsteroidal antiandrogen NSAA. Alpharadin uses bone targeted Radium isotopes to kill cancer cells by alpha radiation. AR belongs to the steroid nuclear receptor family. Development of the prostate is dependent on androgen signaling mediated through AR, and AR is also important for disease progression.

Molecules that could successfully target alternative domains have emerged. Arachidonate 5-lipoxygenase has been identified as playing a significant role in the survival of prostate cancer cells. Galectin-3 is another potential target.
The PIM kinase family is another potential target for selective inhibition. A number of related drugs are under development. It has been suggested the most promising approach may be to co-target this family with other pathways including PI3K. Scientists have established prostate cancer cell lines to investigate disease progression. The LNCaP cancer cell line was established from a human lymph node metastatic lesion of prostatic adenocarcinoma. PC-3 and DU cells were established from human prostatic adenocarcinoma metastatic to bone and to brain, respectively. Elevation of AR expression is often observed in advanced prostate tumors in patients.

These androgen -independent LNCaP cells have elevated AR expression and express prostate specific antigen upon androgen treatment. Paradoxically, androgens inhibit the proliferation of these androgen-independent prostate cancer cells. One active research area and non-clinically applied investigations involves non-invasive methods of tumor detection. A molecular test that detects the presence of cell-associated PCA3 mRNA in fluid obtained from the prostate and first-void urine sample is under investigation. PCA3 mRNA is expressed almost exclusively by prostate cells and has been shown to be highly over-expressed in prostate cancer cells. The higher the expression of PCA3 in the sample, the greater the likelihood of a positive biopsy.
From Wikipedia, the free encyclopedia. For the journal, see Prostate Cancer journal. Male reproductive organ cancer.

This section needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the section and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Further information: Prostate biopsy. Main article: Histopathologic diagnosis of prostate cancer. Main article: Gleason score. Main article: Prostate cancer staging. Sclerosis of the bones of the thoracic spine due to prostate cancer metastases CT image. Sclerosis of the bones of the pelvis due to prostate cancer metastases.
Main article: Prostate cancer screening. Main article: Management of prostate cancer. This section needs additional citations for verification. L’urètre masculin a deux fonctions : évacuer l’ urine pendant la miction et transporter le sperme pendant l’ éjaculation. Le sphincter strié, qui se trouve sous la prostate et autour de l’urètre, aide en se contractant à la vidange des glandes et à expulser le sperme pendant l’éjaculation. Pour fonctionner correctement, la prostate a besoin d’ androgènes hormones masculines.

Le liquide prostatique est un liquide alcalin qui a pour fonction de neutraliser l’acidité vaginale.
Un élément capable d’empêcher la coagulation du sperme est également sécrété par la prostate. L’examen de la prostate par un médecin s’effectue par un toucher rectal. Le médecin introduit un doigt, protégé d’un doigtier lubrifié, dans le rectum du patient. La prostate peut ainsi être palpée par sa face postérieure. La taille en est appréciée, et un nodule peut être détecté. L’examen est la plupart du temps indolore. La concentration sérique de l’ antigène prostatique spécifique PSA est augmentée en cas de cancer de la prostate , mais aussi dans certaines pathologies bénignes.
L’ échographie prostatique utilise les ultrasons et leur réflexion pour obtenir une image. La sonde émettrice et réceptrice lubrifiée est introduite dans le rectum du patient et permet de visualiser ainsi la prostate.

Cet examen est, en règle générale, indolore et sans danger. Dans le cadre du cancer, l’échographie peut visualiser des anomalies de la paroi prostatique qui aident à stadifier la maladie. Aussi, la grande majorité des biopsies prostatiques sont effectuées par voie transrectale à l’aide de l’échographie qui guide précisément les prélèvements. Ces prélèvements 10 environ ont l’avantage de se faire sous anesthésie locale.
L’échographie abdominale permet également de visualiser les reins , les bassinets et les uretères afin de voir le retentissement de l’obstacle prostatique en amont. Elle permet aussi de mesurer un éventuel résidu vésical après miction ou « résidu post mictionnel » très fréquent dans les hypertrophies obstructives de la prostate adénome. On peut essayer de quantifier l’obstacle secondaire à l’ hypertrophie prostatique section Adénome ci-dessous par un bilan urodynamique , en mesurant la pression intravésicale dans la vessie par l’introduction d’une petite sonde. On peut de même évaluer le débit et la force du jet d’ urine.

La radiologie est passée au second plan depuis l’avènement de l’échographie dans l’exploration de la prostate.
L’injection intraveineuse d’un produit iodé lors d’une UIV urographie intraveineuse permet de visualiser l’ensemble des voies urinaires et de détecter une empreinte prostatique au col de la vessie si l’organe est augmenté de volume. Cet examen est soumis aux risques de toute injection de produits de contraste iodés : problèmes d’ allergie et insuffisance rénale aiguë. L’ IRM est un examen de choix pour toutes les explorations de la prostate, principalement pour le bilan d’un cancer de prostate, qu’il soit connu ou occulte patients présentant une suspicion clinique ou biologique de cancer, mais avec une ou plusieurs séries de biopsie négative. Dans certains centres, on réalise même l’IRM avant les biopsies prostatiques pour améliorer leur rendement.
On peut aussi utiliser l’IRM pour décrire certaines malformations rares affectant la prostate.

L’exploration par IRM s’effectue à l’aide d’une antenne spécifique placée soit dans le rectum du patient à l’instar de l’échographie , soit autour du bassin antenne pelvienne. Dans le premier cas, l’étude de la prostate peut bénéficier d’une étude métabolique par spectroscopie RMN SRMN [ 2 ] ; dans l’autre, l’étude de la perfusion prostatique après injection d’un produit de contraste [ 3 ] ou l’imagerie de diffusion améliorent sa performance. L’adénome de la prostate est une tumeur bénigne ; c’est une entité anatomo-pathologique qui correspond à la présence de nodules fibro-épithéliaux dans le stroma. Cette condition est connue comme hypertrophie bénigne de la prostate ou hyperplasie bénigne de la prostate et peut être traitée avec des médicaments ou grâce à la chirurgie ablation d’une partie de la prostate.

Ce type de chirurgie de nos jours est habituellement exécuté avec un long instrument introduit par l’urètre, le résecteur, qui permet d’introduire un courant électrique monopolaire ou bipolaire , ou une fibre « laser » qui minimise le saignement, sans avoir recours à une incision externe. Une prostatite est une inflammation de la prostate. Si la prostate se développe trop, elle peut resserrer l’urètre et ainsi perturber l’écoulement de l’urine. Cela rend la miction difficile et douloureuse et dans des cas extrêmes complètement impossible. La prostatite est traitée avec des antibiotiques , le massage de la prostate ou la chirurgie. Chez des hommes âgés, ce trouble est fréquent. En France, le cancer de la prostate est le deuxième cancer le plus fréquent chez l’homme de plus de 55 ans, après le cancer du côlon plus de 70 nouveaux cas en [ 4 ].
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Cancer de prostată – Wikipedia

Cáncer de próstata - Wikipedia, la enciclopedia libre
Câncer de próstata português brasileiro ou cancro da próstata português europeutambém denominado de carcinoma da próstataé uma neoplasia que tem seu desenvolvimento na próstatauma glândula do sistema reprodutor masculino. A maioria dos cânceres de próstata d de crescimento lento, no entanto, alguns crescem relativamente rápido. As células cancerosas podem espalhar-se a partir da próstata para Cander partes do corpo, particularmente os ossos e os linfonodos. Inicialmente pode ser assintomática, mas em estágios avançados pode causar dificuldade para urinarpresença de sangue na urina ou dor na pelve, costas ou ao urinar. Os sinais clínicos são muito semelhantes aos da hiperplasia benigna da próstata. Outros sintomas tardios podem incluir sensação de cansaço devido aos baixos níveis de células vermelhas no sangue e disfunção erétil.

As taxas de incidência deste tipo de carcinoma variam amplamente no mundo : o câncer é menos comum no sul e leste da Ásia e mais comum na Europa prosatte Estados Cancer de prostate wikipedia. Este tipo de câncer se desenvolve mais frequentemente em homens acima dos 50 anos de idade. Ocorre somente em homens, já proshate a próstata Cancer de prostate wikipedia uma glândula exclusiva deste sexo. É o tipo de câncer mais comum em homens nos Estados Unidospaís em que é a segunda maior causa de mortes masculinas por câncer, atrás somente do câncer de pulmão. Entretanto, muitos homens que desenvolvem câncer de próstata não apresentam sintomas e acabam morrendo por outras causas. Muitos fatores, incluindo genética e dietawiikipedia sido relacionados ao desenvolvimento do câncer de próstata. O câncer de próstata é mais frequentemente descoberto através de exame físico ou por monitoração dos wikipwdia de sanguecomo o teste do „PSA” sigla em inglês para antígeno prostático específico.

Atualmente existe alguma preocupação sobre a acurácia do Cancer de prostate wikipedia de PSA e Cancer de prostate wikipedia real utilidade. Uma suspeita de câncer de próstata é tipicamente confirmada ao se remover uma amostra da próstata biópsia e examinando-a sob microscópio.

Prostate cancer

Cancer de prostată

The prostate is both an accessory gland of the male reproductive system and wikipediaa muscle-driven mechanical switch between urination and ejaculation. It is found only in some mammals. It differs between Cancer de prostate wikipedia anatomically, chemically, and physiologically. Anatomically, the prostate is found below the bladderwith the urethra passing through it. It is described in gross anatomy as consisting of lobes, and in microanatomy by zone.

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