Fibrosis reversibil in prostate

Fibrosis of the prostate (another name for sclerosis of the prostate) is an ailment that often affects representatives of the strong half of humanity. It develops in men of different age groups. It is characterized by inflammation of the urethra, which develops as a result of the rapid proliferation of connective tissue. Fibrosis of the prostate are the 4 stages of development. At one stage of changes functional changes, which occur during the process of urination. The next step is the violation of passage of urine in the upper and lower channels of the urinary tract. Stage 3 there are pronounced changes of the organs that relate to the structure. LUTD involving the prostate is associated with both ageing and inflammation.

Tissue inflammation resulting from ageing, infection, or other inflammatory disease processes (for example, type 2 diabetes mellitus) is epidemiologically associated with the subsequent development of tissue fibrosis in multiple organ systems, including the prostatita.adonisfarm.ro by: We will then examine the reversibility abnormal voiding behavior and prostate fibrosis when inflammation subsides. Three specific aims examine the hypothesis that prostatic inflammation causes urinary frequency by producing detrusor overactivity and causes bladder outlet obstruction by inducing prostatic fibrosis.

Fibrosis reversibil in prostate

In case of a disease, they narrow because they are squeezed by an overgrown connective tissue, so the stones can not pass. Picrosirius red staining was Fibrosis reversibil in prostate on serially sectioned tissues. I agree. Magnification, × The stage of disease and their characteristics Most experts believe that the causes of changes to the fibrous type associated with the pathological development, the influence of mechanical type on the body, allergic and immunological factors. An increase in β-catenin and α-SMA expression was observed in CP tissues compared with the control group, and resveratrol treatment of CP rats significantly reduced the expression of β-catenin and α-SMA Fig. The presence of urinary tract obstruction was revealed in patients with CP following Fibrosis reversibil in prostate examination 2. Copyright: © Zeng et al.
11/3/ · Periurethral tissue fibrosis may reduce the flexibility and capacity of the prostatic urethra to expand to accommodate urinary flow, which may lead to symptoms associated with obstruction.

Fibrosis is a connective tissue remodeling process that is characterized by the activation and accumulation of myofibroblasts, of which α-SMA is a marker. The present study revealed that α-SMA expression was Cited by: 5.

Prostatic fibrosis, lower urinary tract symptoms, and BPH

Molecular Medicine Reports Symptoms will be very pronounced, so Fibrosis reversibil in prostate disease will not be difficult to diagnose. Environ Toxicol Pharmacol. The surrounding tissue is not injured. In this case, the surgeon carries out the perineal section and removes the stones. Over the past decades, a variety of animal models of prostatitis have been established with the aim of deciphering the pathogenesis of CP. Wuhan, China. B Increased collagen content arrows was observed in the CP group compared with the control group. However, to the best of our knowledge, no reports have investigated the effect of resveratrol on mast cell induced fibrosis in prostatitis. The results of the bladder pressure and volume test Fibrosis reversibil in prostate that the maximum capacity of the bladder, maximum voiding pressure and residual urine volume in the control group were 0.

To test the hypothesis that inflammation produces irritative symptoms, we will examine the correlation of inflammation with detrusor overactivity.

To test the hypothesis that fibrosis produces obstruction, we will examine the correlation between if fibrosis and increased urethral resistance. We will perform mechanistic studies using an established mouse model of prostatic inflammation in which we have shown that inflammation induces a significant increase in voiding frequency and prostatic fibrosis. We will then examine the reversibility abnormal voiding behavior and prostate fibrosis when inflammation subsides. Three specific aims examine the hypothesis that prostatic inflammation causes urinary frequency by producing detrusor overactivity and causes bladder outlet obstruction by inducing prostatic fibrosis.
Specific Aim 1. Specific Aim 2. Test the hypothesis that chronic prostate inflammation induces detrusor overactivity and increased voiding frequency. The increasing global antibiotic resistance also significantly affects management of UTI in men, and therefore calls for alternative strategies. Prostatic inflammation has been suggested to contribute to the etiology of lower urinary tract symptoms LUTS by inducing fibrosis.

Several studies have shown that prostatic fibrosis is strongly associated with impaired urethral function and LUTS severity. Fibrosis resulting from excessive deposition of collagen is traditionally recognized as a progressive irreversible condition and an end stage of inflammatory diseases; however, there is compelling evidence in both animal and human studies to support that the development of fibrosis could potentially be a reversible process.
Prostate inflammation may induce fibrotic changes in periurethral prostatic tissues, promote urethral stiffness and LUTS. MCs have an essential role in fibrosis, and their phenotype and function during resveratrol treatment for CP was investigated in the present study. Rat prostates were immediately acquired following sacrifice for western blot analysis and immunohistochemical assays.
Western blotting revealed that the expression levels of tryptase protein in the prostate of the CP group was increased significantly compared with the control group Fig. However, resveratrol treatment of CP rats significantly decreased expression of this protein compared with the CP group Fig.

The expression of chymase was not detected using western blotting in any of the groups Fig. Immunohistochemical staining indicated that, compared with the control group Fig. Resveratrol treatment of CP rats resulted in a significant reduction in MC number in prostate tissue Fig.
Effect of resveratrol on the expression of tryptase and chymase proteins in the prostates of CP rats. Compared with the control group, tryptase was significantly upregulated in the CP group, and the upregulation was significantly suppressed by resveratrol treatment. However, chymase was not detected in any of the groups. The bar graph presents the relative expression ratio of tryptase calculated following normalization to β-actin. Data are presented as the mean ± standard deviation.
MC infiltration in the prostates. Tissues were stained using immunohistochemistry for tryptase.

Tryptase-positive MC arrows infiltration occurred around the gland area in the stroma. MC, mast cell; CP, chronic prostatitis. TGF-β is a profibrotic cytokine that induces macrophage and fibroblast proliferation via the induction of other growth factors. Western blot analysis revealed an increased expression level of TGF-β in the CP group compared with the control group, which was significantly decreased following resveratrol treatment Fig.
An increase in β-catenin and α-SMA expression was observed in CP tissues compared with the control group, and resveratrol treatment of CP rats significantly reduced the expression of β-catenin and α-SMA Fig. Compared with the control group, the expression of the proteins was significantly upregulated in the CP group. However, the upregulation was significantly suppressed by resveratrol treatment.

The bar graph presents the relative expression ratio of each protein calculated following normalization to β-actin. Picrosirius red staining indicated that, compared with the control group Fig. Effect of resveratrol on collagen accumulation in the prostates of CP rats. Tissues were stained for collagen with picrosirius red. A Picrosirius red staining of prostate tissues in the control group.
B Increased collagen content arrows was observed in the CP group compared with the control group. C Collagen content in CP rats was reduced following resveratrol treatment.

Chronic prostatitis is a common disease in urology and voiding dysfunction is the primary clinical manifestation. The presence of urinary tract obstruction was revealed in patients with CP following urodynamic examination 2. The maximum capacity of the bladder is assessed as a parameter of storage function, and the residual urine volume and maximum voiding pressure are evaluated as parameters of voiding function. In the present study, the maximum capacity of the bladder, residual urine volume and maximum voiding pressure in rats in the CP group were increased significantly compared with the control group.
However, following treatment with resveratrol, these changes were suppressed. We hypothesized that increased collagen accumulation in the prostate during CP progression is a consequence of fibrosis, which increases tissue stiffness. Periurethral tissue fibrosis may reduce the flexibility and capacity of the prostatic urethra to expand to accommodate urinary flow, which may lead to symptoms associated with obstruction.

Fibrosis is a connective tissue remodeling process that is characterized by the activation and accumulation of myofibroblasts 24 , of which α-SMA is a marker. The present study revealed that α-SMA expression was significantly higher in the CP group compared with the control group, and resveratrol treatment of CP rats decreased α-SMA expression.
Picrosirius red staining demonstrated markedly increased collagen content in the CP group compared with the control group, and the maximum capacity of the bladder, residual urine volume and maximum voiding pressure in the CP group increased significantly compared with the control group. However, resveratrol treatment suppressed these alterations. MCs are important effector cells in tissue fibrosis that express the serine proteases, tryptase and chymase, which are the most abundant proteins in MCs.
Tryptase and chymase have been reported to stimulate the proliferation of fibroblasts, induce collagen synthesis in fibroblast cultures and induce collagen fibril formation 25 , However, limited information is known regarding the involvement of these proteases in CP.

As previously reported 27 , the primary fibrotic role of tryptase in the heart is the induction of MC degranulation, which induces the release of chymase and promotes fibrosis. However, Beghdadi et al 28 reported that MC protease 4, the functional counterpart of human chymase, exhibited antifibrotic potential in acutely induced obstructive nephropathy.
The present study indicated that tryptase may individually induce prostate fibrosis in CP in the absence of chymase. The molecular phenotypic heterogeneity of MC makes them attractive therapeutic targets in various diseases 29 , Therefore, the fibrosis-inducing mechanism, which MC is dependent on, is complex and further studies are required. Studies have demonstrated that MC numbers and staining intensity were associated with increased TGF-β production and interstitial fibrosis 12 , TGF-β-induced fibrosis process primarily occurs via the Smad pathway, which serves a critical role in transmitting TGF-β signals.

Wnt signaling has been reported to skew TGF-β signaling towards dominant signaling via the Smad pathway CP tissues in the present study exhibited increased TGF-β and β-catenin expression, which was reduced in the resveratrol treatment group. Control tissue sections exhibited limited positive expression. Resveratrol 15 , a botanical compound that is derived primarily from the skins of red grapes, has been extensively employed in traditional medicine and also as a dietary supplement.
A previous study demonstrated that resveratrol may inhibit tissue fibrosis in various organs In addition, resveratrol repressed and reversed prostate fibroblast to myofibroblast phenoconversion in vitro In conclusion, the progression of urinary dysfunction in CP may be induced by fibrosis in the prostate. The results of the present study demonstrated the antifibrotic effect of resveratrol. Therefore, resveratrol may be considered as a candidate for the treatment of CP.
MCs are not only important for the periurethral tissue fibrosis in CP, but are also a potential target for therapy.

The study was funded by a project supported by the Natural Science Foundation of Liaoning province grant no. J Urol. View Article : Google Scholar. Asian J Androl. J Urolo. J Hepatol. J Infect Dis. Int J Cancer. Silver RB: Role of mast cells in renal fibrosis. Kidney Int.

[Bacterial prostatitis and prostatic fibrosis: modern view on the treatment and prophylaxis]

Acute and chronic inflammation is a common finding in the adult prostate that has been implicated in the genesis of lower urinary tract symptoms LUTS in aging men. The strong association has generated considerable interest in prostate inflammation and its potential as a therapeutic target to prevent or treat LUTS. We and others have postulated that prostatic inflammation contributes to development of LUTS in two ways: 1 producing irritative voiding symptoms by effects on afferent Fibrosis reversibil in prostate co-innervating the prostate and Fibrosis reversibil in prostate and 2 producing obstructive voiding symptoms by inducing fibrosis in the prostate. We will perform a retrospective analysis of Fibrosis reversibil in prostate treated patients who underwent detailed preoperative urodynamic evaluation to examine the association of inflammation with fibrosis. To test the hypothesis that inflammation produces irritative symptoms, we will examine the correlation of inflammation with detrusor overactivity.

To test the hypothesis that fibrosis produces obstruction, we will examine the correlation between if fibrosis and increased urethral resistance. We will perform mechanistic studies using an established mouse model of prostatic inflammation in which we have shown that inflammation induces a significant increase in voiding frequency and prostatic fibrosis. We will then examine the reversibility abnormal voiding behavior and prostate fibrosis when inflammation subsides. Three specific aims examine the hypothesis that prostatic inflammation causes urinary frequency by producing detrusor overactivity and causes bladder outlet obstruction by inducing prostatic fibrosis. Specific Aim 1.

Prostatic fibrosis, lower urinary tract symptoms, and BPH

Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License. Fibrosis reversibil in prostate prostatitis CP is a common disease in urology, and voiding dysfunction is the primary clinical manifestation of CP 1which affects the quality of life of patients with CP. Urinary tract obstruction was previously reported in patients with CP upon urodynamic examination 2. Prostate fibrosis is a contributing factor to lower urinary tract symptom LUTS etiology 3. Tissue Fibfosis is reported to be associated with tissue damage caused by various factors, including aging 4infection reverzibiltumors 6 and additional secondary diseases Fibrosis reversibil in prostate various organs, which leads to dysfunction.

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